| 
                             1947 
 Kosei Suisan K.K. established in Minato-ku, Tokyo. Kurihama Plant opens in Kanagawa.  | 
    
| 
                             1950 
 Industrial production of chondroitin sulfate as a pharmaceutical begins.  | 
    
| 
                             1952 
 Head Office relocated to Chuo-ku, Tokyo.  | 
    
| 
                             1953 
 Name of company changed to K.K. Seikagaku Kenkyusho.  | 
    
| 
                             1960 
 Tokyo Research Institute opens in Shinjuku-ku, Tokyo. Development and marketing of research biochemicals begins.  | 
    
| 
                             1962 
 Name of company changed to Seikagaku Corporation.  | 
    
| 
                             1968 
 Tokyo Research Institute relocated to Higashiyamato-shi, Tokyo.  | 
    
| 
                             1975 
 Takahagi Plant opens in Ibaraki.  | 
    
| 
                             1981 
 World's first endotoxin colorimetry reagent developed and manufactured.  | 
    
| 
                             1987 
 Marketing begins for hyaluronic acid formulations ARTZ and OPEGAN.  | 
    
| 
                             1989 
 Company stock registered with the Japan Securities Dealers Association.  | 
    
| 
                             1992 
 Overseas marketing of ARTZ begins (Sweden).  | 
    
| 
                             1993 
 Marketing begins for ARTZ Dispo, a new formulation.  | 
    
| 
                             1997 
 Acquisition of Associates of Cape Cod, Inc. (U.S.A.)  | 
    
| 
                             1998 
 Quality Management System certification ISO 9001/EN 46001, ISO 13485 obtained (superseded by ISO 13485 certification since 2010).  | 
    
| 
                             2000 
 Name of Tokyo Research Institute changed to Central Research Laboratory.  | 
    
| 
                             2001 
 Marketing begins for hyaluronic acid formulation SUPARTZ in U.S.A.  | 
    
| 
                             2004 
 Listing moved to the Tokyo Stock Exchange, Second Section.  | 
    
| 
                             2005 
 Listing moved to the Tokyo Stock Exchange, First Section. Head Office relocated to Chiyoda-ku, Tokyo.  | 
    
| 
                             2007 
 Marketing begins for a hyaluronic acid medical device MucoUp. Seikagaku Biobusiness Corporation established.  | 
    
| 
                             2012 
 Marketing begins for a single injection hyaluronic acid formulation Gel-One in U.S.A. Absorption-type Merger of Seikagaku Biobusiness Corporation.  | 
    
| 
                             2013 
 CMC Laboratory established.  | 
    
| 
                             2016 
 Marketing begins for SHELLGAN 0.5 Ophthalmic viscoelastic devices for the ophthalmic surgcal aid in Japan.  | 
    
| 
                             2018 
 Marketing begins for HERNICORE 1.25 Units for Intradiscal Injection in Japan.  | 
    
| 
                             2019 
 Marketing begins for HyLink Intra-articular single-injection viscosupplement for the treatment of knee osteoarthritis in Italy.  | 
    
| 
                             2020 
 Acquisition of Dalton Chemical Laboratories, Inc. (Canada).  | 
    
| 
                             2021 
 Marketing begins for JOYCLU 30mg Intra-articular Injection, a Joint Function Improvement Agent, for the Indication of Osteoarthritis (Knee Joint and Hip Joint) in Japan.  | 
    
| 
                             2021 
 Marketing begins for HyLink Intra-articular single-injection viscosupplement for the treatment of knee osteoarthritis in Taiwan.  | 
    
| 
                             2022 
 Listing moved to the Tokyo Stock Exchange, Prime Market.  | 
    













