As a pioneer in glycoconjugate research, Seikagaku uses its own technologies and know-how, and is well trusted as a pharmaceutical company that makes high quality products. Seikagaku manufactures and markets pharmaceutical products containing hyaluronic acid, a major component of glycoconjugates. As the society continues to age, these products improve people's Quality of Life.
| Therapeutic Category | Brand Name | Generic Name | Launch Date |
|---|---|---|---|
| Joint function improving agent | ARTZ®25mg | Hyaluronic acid | March 1987 |
| Joint function improving agent | ARTZ Dispo®25mg | Hyaluronic acid | February 1993 |
ARTZ® is the world's first joint function improving agent whose main ingredient is hyaluronic acid. It was developed based on the knowledge that hyaluronic acid is an important component of joint fluid. By being directly injected into the joint, the drug can help improve ailments common among seniors, such as osteoarthritis of the knee, periarthritis of the shoulder, and knee joint pain of rheumatoid arthritis.
ARTZ Dispo® is a pre-filled syringe, eliminating the time it takes to aspirate the drug solution (hyaluronic acid) from the ampule.
ARTZ® has been approved in 21 countries, including Japan, the US, Europe, and several countries in Asia. It is widely trusted by medical society and more than 200 million injections have already been administered worldwide.

ARTZ®25mg

ARTZ Dispo®25mg
| Therapeutic Category | Brand Name | Generic Name | Launch Date |
|---|---|---|---|
| Ophthalmic surgical aid | OPEGAN Hi®0.7 | Hyaluronic acid | August 1995 |
| Ophthalmic surgical aid | OPEGAN Hi®0.85 | Hyaluronic acid | July 1999 |
| Ophthalmic surgical aid | OPEGAN®0.6 | Hyaluronic acid | July 1999 |
| Ophthalmic surgical aid | OPEGAN®1.1 | Hyaluronic acid | July 1999 |
The ophthalmic surgical aid OPEGAN® was the first hyaluronic acid formulation produced in Japan. As hyaluronic acid has a high level of viscoelasticity, it is used primarily in cataract surgery to anterior chamber expansion. It also protects the corneal endothelium.
OPEGAN Hi® achieves a higher level of viscoelasticity by using hyaluronic acid with a greater molecular weight than in the original OPEGAN.
We offer four products in different quantities and levels of viscoelasticity in order to allow physicians to select the product that best meets their needs.
![]() |
![]() |
![]() |
![]() |
| OPEGAN Hi®0.7 | OPEGAN Hi®0.85 | OPEGAN®0.6 | OPEGAN®1.1 |
By injecting MucoUp® as a surgical aid into the sub-mucosal layer at the lesion of tumors in the gastrointestinal tract, the lesion rises to form a dome that can be more easily, safely and completely removed by endoscopic mucosal resection.

MucoUp®